You can take Tylenol which is out of date for a short time, if the Tylenol has been kept refrigerated, tightly sealed and very dry. Otherwise, it should be disposed of. Otherwise, it should be. Yes, you can take Tylenol (acetaminophen) with Motrin (ibuprophen) as long as you follow the dosage instructions for each one appropriately. share with friends Share to: Ouch, I'm not surprised you has side effects! 1050mgs is a hefty dose of lithium and ibuprofen can increase your blood lithium levels. Acetaminophen (Tylenol) is the only OTC analgesic that's not an NSAID like ibuprofen. Advil – The exact mechanism is not understood, but lithium combined with ibuprofen medications like Advil can cause toxic levels of lithium in the blood. Lithium drug interactions with Advil are rare, but close monitoring is recommended when taking these two medications together. There's all kinds of stuff out there that they didn't have when I was taking Lithium but, not much new over the counter that you can take. It's like tylnol and all that stuff the drug companies are going to wring every penny out of it from prescriptions before they put it over the counter. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Do those of you on Lithium, do you take ibuprofen. If not, how do you manage certain types of pain. If not, how do you manage certain types of pain. Sign Up or Login to comment. Can I take Lithium with Tylenol PM? There is a moderate interaction between Lithium and Tylenol PM. You may want to consider another combination. Summary. Drug interactions are reported among people who take Lithium carbonate and Tylenol together. This study is created by eHealthMe based on reports of 198 people who take Lithium carbonate and Tylenol from FDA, and is updated regularly.